Formulation development for small molecules is a nuanced process crucial for optimising drug delivery, efficacy, and safety. Key aspects of formulation development encompass a thorough understanding of the physicochemical properties of the active pharmaceutical ingredient (API). Additionally, formulation development for small molecules is intricately linked with the product target profile, which outlines the desired characteristics and performance of the drug product. Understanding the target profile guides formulation scientists in tailoring the formulation to meet specific therapeutic goals, patient needs, and regulatory requirements. This presentation will delve into the dynamic interplay among formulation strategies, API characteristics, and example target profiles, elucidating how they shape the design and optimisation of small molecule therapeutics.